No depot for alum

Antigen depot is not required for alum adjuvanticity

Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation and subsequent T- and B-cell responses, this has never been formally proven. To examine antigen persistence, we used the chimeric fluorescent ...

Development of Model and Algorithm for Depot Balancing Multi-Depot Vehicle Scheduling Problem Considering Depot Balancing

The main of multi-depot vehicle scheduling problem (MDVSP) is to schedule the timetabled trips using limited resources, optimally. The problem is very important in the management of the transportation systems. One of the most useful ways to better manage these systems is to consider the real conditions including depot balancing constraints. To normalize the number of vehicles departed from each...

Alum Coagulation

An Interactive Allocation for Depot-Customer-Depot in a Multi Aspect Supply Chain Network

Supply chain excellence has a real huge impact on business strategy. Building supply chains (SCs) as flexible system represents one of the most exciting opportunities to create value. This requires integrated decision making amongst autonomous chain partners with effective decision knowledge sharing among them. The key to success lies in knowing which decision has more impact on the supply chai...

Efficacy of alum for treatment of recurrent aphthous stomatitis

Background: Recurrent aphthous stomatitis (RAS) is the most common painful ulcers of oral mucosal which can cause many sufferings. Treatment of RAS often includes administration of corticosteroids, analgesics and regulators of the immune system. However, considering the side effects of these medications, even their topical application must be done with caution. Alum is used in traditional medic...